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lit_disc_quiz_3 - 7.91/BE.490 Foundations of Computational...

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7.91/BE.490: Foundations of Computational and Systems Biology Literature Discussion Quiz #3 Due 05/06/04 at the beginning of class Nat Genet. 2003 Jun;34(2):166-76. Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data. Segal E, Shapira M, Regev A, Pe'er D, Botstein D, Koller D, Friedman N. The authors often refer to “modules” and “regulation programs”. Briefly define the two terms. Exactly what information does a gene expression microarray experiment give? With this in mind, what assumptions did the authors need to make in order to infer cellular regulation networks from microarray data? If the expression levels of genes A and B are correlated, in general, it is hard to tell whether they are correlated because A regulates B, B regulates A, A and B are regulated by some C or even something else. How did the authors go around this problem of distinguishing between correlation and regulation?
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