micfluiprolab_03 (1)

micfluiprolab_03 (1) - MASSACHUSETTS INSTITUTE OF...

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MASSACHUSETTS INSTITUTE OF TECHNOLOGY Department of Electrical Engineering and Computer Science Department of Mechanical Engineering Division of Bioengineering and Environmental Health Harvard-MIT Division of Health Sciences and Technology Quantitative Physiology: Cells and Tissues 2.791J/2.794J/6.021J/6.521J/BE370J/BE470J/HST541J Fall, 2003 MicroFluidics Project Laboratory Introduction This page contains helpful information about the proposal, experimentation, analysis, and report-writing stages of this laboratory. You should read through it at each stage to make sure you understand what is required. Overview This laboratory project is intended to provide an opportunity to learn about 1. designing an experiment, 2. acquiring, processing, and interpreting experimental data, and 3. communicating the results to others. This laboratory project is also intended to introduce the emerging field of microfluidics. Microfluidics refers to the use of devices in which fluid flows are restricted to channels with micrometer dimensions. Such devices are interesting for at least 3 reasons: 1. Microfluidic devices can be manufactured using photolithographic techniques that allow many devices to be constructed simultaneously (just as modern electronic devices are manufactured). Bulk manufacturing reduces the cost per device.
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2. Since they are small, many devices can be fit into a small volume, leading to the idea of total "labs-on-a-chip" replacing labs that occupy benches or even whole rooms today. 3. Flows in microscopic chambers can exhibit behaviors that are difficult or impossible to produce in macroscopic chambers. These flow regimes can be used to simplify measurements that are difficult or impossible to make macroscopically. This laboratory project is intended to take advantage of microfluidics to measure the properties of molecular transport by diffusion. Microfluidics More than any other single factor, bulk fabrication has made possible today's vast array of powerful and inexpensive electronic devices. The millions of components in a modern computer are fabricated in parallel, making the manufacture of such integrated circuits little more costly than the manufacture of circuits that contain only tens of components. Similar bulk fabrication techniques are currently being developed for fluidic devices, and the resulting microfluidic devices hold promise to similarly revolutionize chemical and biochemical analysis systems. For example, the integration of all of the components needed for the sequencing of DNA (i.e., valves to control flows, incubation chambers, mixing chambers, heating/cooling chambers) may soon allow "labs-on-a-chip" to replace whole biochemistry labs. Microfluidic devices are smaller than conventional macrofluidic components, and their
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This note was uploaded on 11/11/2011 for the course BIO 2.797j taught by Professor Matthewlang during the Fall '06 term at MIT.

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micfluiprolab_03 (1) - MASSACHUSETTS INSTITUTE OF...

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