MIT20_441JF09_lec02c_ms

MIT20_441JF09_lec02c_ms - Massachusetts Institute of...

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UNIT CELL PROCESSES Bone Remodeling Massachusetts Institute of Technology Harvard Medical School Brigham and Women’s Hospital VA Boston Healthcare System
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Bone (Trabecular) Structure Osteoporotic: Postmenopausal Normal Effects (bone resorption) of the alteration in chemical regulator (lack of estrogen). Two photos removed due to copyright restrictions. Postmenopausal bone is much less dense.
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Slope = ~2 0.1 1 10 100 0.01 0.10 1.00 Apparent density (g/cc) Ultimate strength (MPa) Figure by MIT OpenCourseWare. Data from AAOS Orthop. Basic Sci., 2000.
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UNIT CELL PROCESSES FIBROUS TISSUE REMODELING Fibroblast + ECM Sol. ECM + Reg . Fibroblast + ECM New ECM + Reg . Reg. Synthesis: collagenase Synthesis: collagen
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UNIT CELL PROCESSES BONE REMODELING Osteoclast + ECM Sol. ECM + Reg . Osteoblast + ECM New ECM + Reg . Degradation Formation Synthesis: collagenase, H + Synthesis: collagen
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BONE REMODELING Osteoclast + ECM Sol. ECM + Reg . Osteoblast +
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This note was uploaded on 11/11/2011 for the course BIO 2.797j taught by Professor Matthewlang during the Fall '06 term at MIT.

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MIT20_441JF09_lec02c_ms - Massachusetts Institute of...

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