MIT20_441JF09_lec06_iy

MIT20_441JF09_lec06_iy - 2.79J/3.96J/20.441J/HST522J...

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2.79J/3.96J/20.441J/HST522J Biomaterials-Tissue Interactions ECM does not regenerate spontaneously OR Injury to ECM is Irreversible
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Reversible and Irreversible injury
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Reversible injury Spontaneous regeneration of amputated limb in the newt occurs independently of severity of injury Goss, 1992 Figure removed due to copyright restrictions. See Figure 1.1 in [TORA]. [TORA] = Yannas, I. V. Tissue and Organ Regeneration in Adults . New York, NY: Springer-Verlag, 2001. ISBN: 9780387952147. [Preview in Google Books ]
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Irreversible injury Burn victim suffering from severe contraction and scar formation Tomasek et al., 2000 Photo removed due to copyright restrictions.
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adult ECM is irreversible Summary : 1. After severe injury, and in contrast to the fetus, the adult heals most organs irreversibly (no regeneration). 2. Most organs are made up of three basic tissues (“tissue triad”): epithelia, basement membrane, and stroma. 3. Epithelia and basement membrane are spontaneously regenerative; the stroma is not. 4. Therefore, the central problem in biomaterials selection for organ replacement by regeneration is synthesis of the stroma. Text
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MIT20_441JF09_lec06_iy - 2.79J/3.96J/20.441J/HST522J...

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