MIT20_441JF09_lec09_iy

MIT20_441JF09_lec09_iy - What is a phenotype? A phenotype...

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Unformatted text preview: What is a phenotype? A phenotype is any observable characteristic or trait of an organism : such as its morphology , development , biochemical or physiological properties, or behavior . Phenotypes result from the expression of an organism's genes as well as the influence of environmental factors and possible interactions between the two. Phenotype changes following cell adhesion on biomaterials Biomaterials surfaces can function as insoluble regulators of cell phenotype. Interactions between cells and their insoluble environment are increasingly important in tissue engineering and regenerative medicine. Several cases of cell phenotype regulation by surfaces of ECM analogs (CGS) will be studied in the following section. Figure by MIT OpenCourseWare. After Ricci Harley, PhD thesis, p. 203, 2006 The migration speed of fibroblasts decreases with average pore size of collagen-GAG scaffolds within the pore size range studied (90-150 m). The migration speed of fibroblasts increases with oungs modulus of collagen-GAG scaffolds. Harley, PhD thesis, p. 199, 2006 The migration speed of prostate cancer cells (DU-145) on a collagen-GAG scaffold is higher than that of normal fibroblasts Grzesiak and Bouvet, Pancreas 34: 220-228, 2007 roliferation rates of various pancreatic cancer cell types on...
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This note was uploaded on 11/11/2011 for the course BIO 2.797j taught by Professor Matthewlang during the Fall '06 term at MIT.

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MIT20_441JF09_lec09_iy - What is a phenotype? A phenotype...

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