MIT20_441JF09_quiz1 - Massachusetts Institute of Technology...

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Massachusetts Institute of Technology 2.79J/3.96J/20.441J/HST522J Fall 2009 Biomaterials - Tissue Interactions Quiz #1 1 (80%). Implants to Treat Defects in the Intervertebral Disc. The intervertebral discs (IVD) of the spine are sandwiched between the bone vertebrae (Fig. 1a). The IVD is made up of an outer “annulus fibrosus” comprised of fibrous tissue with a lamellar structure in which the collagen fibers in each lamella are oriented in a particular angle (Fig. 1b). Contained within the annulus fibrosus, making up the core of the disc, is the “nucleus pulposus,” which is cartilage (Fig. 1b). The bone and annulus fibrosus are vascularized but the nucleus pulposus has no blood vessels. You have been hired by an orthopaedic company interested in developing novel treatments for spine problems. A. (10%) Due to trauma, small fissures/fractures/defects can form in the nucleus pulposus, annulus fibrosus, and/or in the bone (Fig. 1c). Write 3 interconnected unit cell processes, involving 3 different cell types, for the acute phase of healing for each of the 3 defects. Name a regulator for each process if one is known. B. (15%) The company is considering the development of treatments for each of the 3 small defects in Fig. 1c. Which of the elements of tissue engineering/regenerative medicine (scaffolds, cells, regulators), if any, would you suggest are the most essential for implantation or injection into each of the 3 defects to facilitate the most favorable reparative response. You can name more than one element, but there must be a compelling rationale. Explain your answers. C. (15%) In certain disease conditions it is necessary to remove a portion of degenerated annulus fibrosus and nucleus pulposus, in a procedure referred to as discectomy (Fig. 1b). One proposed method of treatment is to implant a permanent, nonporous silicone rubber device which has the same shape as the defect and compressive properties that are similar to the resected tissue. (1) What are two principal issues which would have to be addressed relative to this
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This note was uploaded on 11/11/2011 for the course BIO 2.797j taught by Professor Matthewlang during the Fall '06 term at MIT.

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MIT20_441JF09_quiz1 - Massachusetts Institute of Technology...

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