MIT20_441JF09_quiz3

MIT20_441JF09_quiz3 - Massachusetts Institute of Technology

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Massachusetts Institute of Technology 2.79J/3.96J/20.441J/HST522J Fall 2009 Biomaterials - Tissue Interactions Quiz #3 1 (50%). Design of a study to replace scar with skin. You are working under a very tight budget due to your company’s efforts to survive the recession. You are asked to develop a device for regenerating skin in patients who have scars in their skin of size about 10X10 cm 2 . Each scar will be removed surgically and your new device will be grafted on the freshly generated skin wound. If your device works, skin will be regenerated at the site of the former scar. A (10%). Select an animal species with which you will conduct model studies of your candidate device(s). The animal species you select should have approximately the same scar-forming ability as the human. As a measure of scar-forming ability you can take the fractional percent of initial area of an experimental skin wound that forms scar asymptotically following injury (A ). Since the human forms large scars, the asymptotic scar-forming ability of humans (on the back) is about 45%. The animal species you select should have an asymptotic scar-forming ability of at least 25%. B (10%). Describe the wound model that you will generate in order to test the ability of your device to replace scar. Explain briefly why you are selecting this wound model. C (20%). Consider the following 6 protocols that have been suggested for inducing skin regeneration in your animal model at lowest cost. For each candidate protocol provide a prediction of its efficacy and explain your answer briefly. a. Keratinocytes (KC) + dermis regeneration template (DRT) [in vitro]. It is proposed that new skin will hypothetically be formed in vitro using these two reactants, followed by grafting on this hypothetical skin onto the model wound. DRT is formed by coprecipitating collagen and a glycosaminoglycan in acetic acid solution, followed by freeze drying to form a scaffold with
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MIT20_441JF09_quiz3 - Massachusetts Institute of Technology

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