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MIT20_441JF09_quiz3_sample

MIT20_441JF09_quiz3_sample - 20.441J Fall 2009 Quiz 3...

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20.441J Fall 2009 Quiz 3 Sample problem, as solved in class Synthetic pathways for a new conjunctiva (Yannas). The conjunctiva covers the exposed part of the opaque part of the eye (sclera) and the inner surface of the eyelids. It is made up three tissue types. The epithelial tissue is stratified and contains specialized cells (goblet cells) that synthesize and secrete mucus that contributes to the protective and lubricating layer on the exposed surface of the eye. Underneath the epithelial tissue is a very thin basement membrane and connected to it is the conjunctival stroma, a loose vascular supportive tissue comprising extracellular matrix proteins and blood vessels. See Fig. 1. Wounds in the conjunctiva can be induced by chronic infection (trachoma) that remains untreated (typically due to unavailability of medical care in certain developing economies). Such chronic wounds can be deep, extending into the stroma and eventually closing by contraction and scar formation, processes which block vision. Typically, one eye only is compromised by this condition; however, both eyes may eventually also get involved.. You are working as a consultant in a medical device company that is interested in designing a device to be used in inducing regeneration of the diseased conjunctiva. The device that you will design will be placed in contact with a surgically induced full-thickness square wound, initially measuring 2 x 2 mm 2 in area, in the diseased conjunctiva. A successful device will induce regeneration of all three tissues of the conjunctiva, with recovery of function in less than 8 weeks. In your design consideration you will make the assumption that only one eye has been affected at the time of treatment. Also assume that the conjunctiva has a morphology that is very similar (though not identical) to that of the skin of a rodent. You will also assume that the full-thickness conjunctival wound responds
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