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Unformatted text preview: Harvard-MIT Division of Health Sciences and Technology HST.542J: Quantitative Physiology: Organ Transport Systems Instructors: Roger Mark and Jose Venegas MASSACHUSETTS INSTITUTE OF TECHNOLOGY Departments of Electrical Engineering, Mechanical Engineering, and the Harvard-MIT Division of Health Sciences and Technology 6.022J/2.792J/BEH.371J/HST542J: Quantitative Physiology: Organ Transport Systems PROBLEM SET 1 Assigned: February 3, 2004 Due: February 10, 2004 Problem 1 Certain traumatic injuries such as gunshots or knife wounds to the groin may lead to the develop- ment of a “short circuit” or fistula between the large femoral artery and the adjacent femoral vein. (See Figure 1.) The fistula may have a very low resistance to ﬂuid ﬂow, and may carry large blood ﬂow rates. Figure 1: Two medical students were arguing about the expected effect of a large femoral AV fistula on the blood supply to the leg. One student was certain that the leg would be deprived of its blood supply and would become gangrenous. The other student violently disagreed, and insisted that the leg would be in no danger. Who was correct? A. Propose a simple resistive model to represent the blood supply to the leg with and without the presence of the fistula. The model should include the aorta, the femoral artery, the leg circulation, and the corresponding veins. Assume that the resistance of the fistula (when open) is much lower than the resistance of the leg vascular bed, but higher than the (negli- gible) resistance of the aorta. Assume negligible resistance for the large veins as well as the gible) resistance of the aorta....
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This note was uploaded on 11/11/2011 for the course BIO 2.797j taught by Professor Matthewlang during the Fall '06 term at MIT.
- Fall '06