ps3 - Molecular, Cellular & Tissue Biomechanics, Fall...

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Molecular, Cellular & Tissue Biomechanics, Fall 2006 20.310/2.797J/6.024J/3.053 Problem Set # 3 Problem 1: An early Wormlike Chain model, from Marko-Siggia (1995) for force vs. extension is given below. F WLC k b T L p 1 41 x L c 2 1 4 x L c + := On the Stellar web-site we’ve loaded a real DNA stretching curve obtained with an optical trap. Fit this data trace to this model and extract a contour length, L c and persistence length L p for this data curve. Plot your fit with the data (force vs. extension) and list your results for these two parameters. What region of the curve fits well? Where does the model have trouble? A good way to determine where a fit deviates from the data is to create a “residual trace” where you subtract the data from the fit. If the residuals are near zero, your fit is good. Make a residual trace and multiply by a factor that amplifies this trace relative to your curves (such as a factor of 5). Plot this along with your data and fit curve.
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This note was uploaded on 11/11/2011 for the course BIO 2.797j taught by Professor Matthewlang during the Fall '06 term at MIT.

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ps3 - Molecular, Cellular & Tissue Biomechanics, Fall...

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