ps4 - Molecular, Cellular & Tissue Biomechanics, Fall...

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Molecular, Cellular & Tissue Biomechanics, Fall 2006 20.310/2.797J/6.024J/3.053 Problem Set # 4 Problem 1: From the force-clamped stepping trace below, which you can find on the stellar web-page, generate a pairwise difference distribution (1 or 2nm bins will likely work well for this) and plot this out. From this distribution, plot the corresponding spatial frequency and identify the step size. You can obviously see the steps in the trace below so compare your result to what you get by eye. Problem 2: The following graph shows a plot containing many points where the value of k off as a function of force for receptor ligand bonds for selectin tethers has been determined. According to the points in the graph, determine the length scale of the distance to the transition state δ for tether unbinding. Assume the unloaded k 0 off is 1/s. Problem 3: For the protein below, it is observed that the spontaneous zero load unfolding rate is 4x10 -4 /s and the refolding rate is 2/s. If you apply a force to unfold the
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This note was uploaded on 11/11/2011 for the course BIO 2.797j taught by Professor Matthewlang during the Fall '06 term at MIT.

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ps4 - Molecular, Cellular & Tissue Biomechanics, Fall...

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