ps9 (1) - Harvard-MIT Division of Health Sciences and...

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Harvard-MIT Division of Health Sciences and Technology HST.542J: Quantitative Physiology: Organ Transport Systems Instructors: Roger Mark and Jose Venegas MASSACHUSETTS INSTITUTE OF TECHNOLOGY Departments of Electrical Engineering, Mechanical Engineering, and the Harvard-MIT Division of Health Sciences and Technology 6.022J/2.792J/BEH.371J/HST542J: Quantitative Physiology: Organ Transport Systems PROBLEM SET 9 Assigned: April 15, 2004 Due: April 23, 2004
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Problem 1 Emphysema is one of the leading causes of death in the United States. Our ability to treat emphy- sema is severely limited because the principal physiologic deficiency results from the destruction of the architecture of the lung. The development of lung transplantation was the first direct ap- proach to the treatment of advanced emphysema. However, most patients with severe disease are precluded from undergoing this surgery by advanced age and coexisting conditions. Lung-reduction surgery is the newest therapeutic option for patients with emphysema and one that is potentially available to many more patients. The idea of removing 25 percent or more of the lung from a patient with marginal lung function appears, to say the least, counterintuitive. Nevertheless, in certain patients with emphysema, lung-reduction surgery can result in substantial
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ps9 (1) - Harvard-MIT Division of Health Sciences and...

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