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Unformatted text preview: Harvard-MIT Division of Health Sciences and Technology HST.542J: Quantitative Physiology: Organ Transport Systems Instructors: Roger Mark and Jose Venegas MASSACHUSETTS INSTITUTE OF TECHNOLOGY Departments of Electrical Engineering, Mechanical Engineering, and the Harvard-MIT Division of Health Sciences and Technology 6.022J/2.792J/BEH.371J/HST542J: Quantitative Physiology: Organ Transport Systems QUIZ 1 Tuesday, March 2, 2004 Name: Problem 1 A. Draw normal P ( t ) waveforms for the left ventricle, left atrium, and aorta. Show two com- plete cardiac cycles, and use typical normal values for the pressures. Use the time axis provided in Figure 1.1a, and assume a heart rate of 60 bpm. B. The cardiac output was measured using the Fick method. Oxygen uptake 363 ml O 2 per minute Arterial oxygen content 200 ml O 2 per liter of blood Mixed venous oxygen content 145 ml O 2 per liter of blood Using this data together with your P ( t ) waveforms, draw the corresponding P-V loop for the LV. Assume an end-diastolic LV volume of 170 cc., and a LV dead volume of 15 cc for both systole and diastole. Draw linear systolic and diastolic P-V curves, and use the axes provided. C. Correlate the following landmarks on the P-V loop with the appropriate points on the P ( t ) curves using the numeric labels below: a: begin LV contraction b: peak LV pressure c: begin LV filling d: end ejection e: begin LV ejection D. Ejection fraction (EF) is defined as the percentage of the end-diastolic volume that is ejected during systole. What is the EF in this case? (Normal > 55%.) E. A papillary muscle in the LV ruptures. (Assume that there are no functioning controls, and that the system has reached a new steady state.) The new arterial BP (systolic, diastolic, and that the system has reached a new steady state....
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- Fall '06