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quiz3_solutions

quiz3_solutions - Harvard-MIT Division of Health Sciences...

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Harvard-MIT Division of Health Sciences and Technology HST.542 J : Quantitative Physiology: Organ Transport Systems Instructors: Roger Mark and Jose Venegas MASSACHUSETTS INSTITUTE OF TECHNOLOGY Departments of Electrical Engineering, Mechanical Engineering, and the Harvard-MIT Division of Health Sciences and Technology 6.022J/2.792J/BEH.371J/HST.542J: Quantitative Physiology: Organ Transport Systems QUIZ 3 SOLUTIONS
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These are normal values of physiological parameters for a 70 kg person. R rs (respiratory system R) = 4 mbar · s/l C cw = 200 ml/mbar C lung = 200 ml/mbar V D (Anatomic) = 150 ml V O 2 = 274 ml/min V CO 2 = 220 ml/min RQ = 0.8 Q s / Q T (Shunt fraction) < 0.05 Q T (cardiac output) = 5 l/min P atm = 760 mmHg P v CO 2 = 46 mmHg P v O 2 = 40 mmHg P a CO 2 = 40 mmHg P a O 2 (at room air) = 100 mmHg ( A a ) D O 2 6-10 mmHg pH = 7.4 cHb = 15 g/100ml-blood Hb O 2 Binding capacity = 20.1 ml O 2 /100ml blood FRC = 2.4 l The normal hemoglobin O 2 saturation curve is also included and should be used only when there is no alternative data available. Figure 1: The first two problems are cases that include certain respiratory physiologic abnormalities. You can use the normal values as a reference, or in absence of additional information. 6.022j—2004: Quiz 3 solutions 2
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Problem 1 (Case 1) A patient comes to the emergency ward with shortness of breath and wheezing. He is breath- ing room air at a rate of 30 breaths per minute, and the pulse oximeter shows his arterial blood saturation to be S a O 2 = 0.80. Arterial and mixed venous blood samples are taken at arrival and reveal the following values: P v CO 2 = 44 mmHg P v O 2 = 27 mmHg P a CO 2 = 39 mmHg P a O 2 (at room air) = 20 mmHg The blood gas data comes with a computer generated caution questioning the validity of the measurements.
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