ch1_intro

A dimicco et al response of the chondrocyte to

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Unformatted text preview: "Response of the chondrocyte to mechanical stimuli" in Pathogenesis of Osteoarthritis. (c) and (d) from J. Zaleskas, et al., Biomat. 2004;25:1299. UNIT CELL PROCESSES The "Control Volume" and Regulators Chemical (Soluble) Regulator Figure by MIT OCW. Cell + Matrix Molecules (Insoluble Reg.) UCP Product + Soluble Regulator "Control Volume" UNIT CELL PROCESSES The "Control Volume" and Regulators Chemical (Soluble) Cell Biology Subjects Regulator Figure by MIT OCW. Cell + Matrix Molecules (Insoluble Reg.) UCP Product + Soluble Regulator "Control Volume" UNIT CELL PROCESSES The "Control Volume" and Regulators Chemical (Soluble) Regulator Figure by MIT OCW. Cell + Matrix Molecules (Insoluble Reg.) UCP Product + Soluble Regulator Biomaterials "Control Volume" 2.79 UNIT CELL PROCESSES The "Control Volume" and Regulators Chemical (Soluble) Regulator Mechanical Exogenous Force (Strain); MF Physical Regulator Figure by MIT OCW. 2.785 Cell + Matrix Molecules (Insoluble Reg.) UCP Product + Soluble Regulator "Control Volume" UNIT CELL PROCESSES The "Control Volume" and Regulators Chemical (Soluble) Regulator Mechanical Force (Strain); Physical Regulator 2.785 Figure by MIT OCW. Cell + Matrix Molecules (Insoluble Reg.) UCP: Contraction Product + Soluble Mech. Force Regulator Endogenous MF "Control Volume" UNIT CELL PROCESSES The "Control Volume" and Regulators Chemical (Soluble) Regulator Mechanical Force (Strain); Physical Regulator UCP: Contraction Cell + Matrix Molecules Product + Soluble Mech. Force Regulator Shield cells from stress Deformed by cell Excessively load cells Biomaterials/ contraction Promote cell contraction Implants UNIT CELL PROCESSES The "Control Volume" and Regulators Mechanical Force (Strain); Physical Regulator Cell + Matrix Molecules (Insoluble Reg.) Figures by MIT OCW. The strain experienced by the cell will depend on the loaddeformation behavior (modulus of elasticity) of the Matrix CELL-MATRIX MECHANICS How cells respond to mechanical force Load-deformation of the matrix How cells generate mechanical forces UNIT CELL PROCESSES The "Control Volume" and Regulators Chemical (Soluble) Cell Biology Subjects Regulator Cell + Matrix Molecules (Insoluble Reg.) UCP Product + Soluble Regulator "Control Volume" Bone (Trabecular) Structure Normal Osteoporotic: Postmenopaus...
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This note was uploaded on 11/11/2011 for the course BIO 20.410j taught by Professor Rogerd.kamm during the Spring '03 term at MIT.

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