ch1_intro

Cell matrix mechanics clinical examplesmedical

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Unformatted text preview: w of the tissue expanders being inflated. CELL-MATRIX MECHANICS Clinical Examples/Medical Devices How cells respond to mechanical force Excessively loading cells Distraction osteogenesis (bone lengthening) Limb Lengthening Distraction Osteogenesis Photos removed for copyright reasons. Gavriel Illizarov, M.D., Russian Orthopaedic Surgeon http://www.ilizarov.com/english/limb_lenghtening.asp Insertion of the intramedullary nail and osteotomy; The corticotomy is completed percutaneous with a corticotome. Application of the external fixator Photo removed for copyright reasons. Distraction (the method of taking the bony fragments away from each other) is started in the tenth day. The rate of the distraction should be 0.25 mm four times a day. Photo removed for copyright reasons. Sacrifice 5 days after a 13-day distraction period Rat Model Photos removed for copyright reasons. Kinner B, et al. J. Orthop. Res. 2003;21:20 Cranial Deformation Photos removed for copyright reasons. CELL-MATRIX MECHANICS Clinical Examples/Medical Devices How cells respond to mechanical force Excessively loading cells Ultrasound stimulation of fracture healing Sonic Accelerated Fracture Healing System Exogen 2000 Low-intensity ultrasound (lower than a fetal sonogram) Accelerates fracture healing by 38% Prescribed by physicians Used by patients at home or work 20 minute treatment time once per day Osteoporosis Studies New and unique mechanical stress technology Non-pharmaceutical therapy Subject of pre-clinical studies Demonstrated prevention of bone loss and increase in bone mass (animal studies) Currently being studied in post-menopausal women Clinical Use Prescribed for more than 15,000 fractures Prescribed by over 6,000 physicians Reimbursed by more than 800 insurers Source: http://ortho.smith-nephew.com/au/Category.asp?NodeId=2480 The Role of Ultrasound in Fracture Healing See Smith & Nephew slide presentation online at http://ortho.smith-nephew.com/nl/Category.asp?NodeId=1453 (last accessed 25 January 2005) CELL-MATRIX MECHANICS Clinical Examples/Medical Devices How cells respond to mechanical force Promoting cell contraction How cells generate mechanical forces Deformation of biomaterials/implants Tissue contracture Scar Contracture after a Burn Injury Photos removed for copyright reasons. What cells are responsible for this? Treatments? Food and Drug Administration Breast Implant Complications Photographs of Breast Implant Complications http://www.fda....
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