hepat_virus_immu

hepat_virus_immu - Hepatitis virus immunity Mar 9, 2005...

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Hepatitis virus immunity Mar 9, 2005 Rehermann and Nascimbeni review Crispe review
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• Both viruses cause immune-mediated active and chronic hepatitis •HBV – Vertical transmission = chronic hepatitis – Adult infection = protective immunity •HCV – Adult infection = 60-80% chronic hepatitis
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Clinical features Feature Hepatitis B Hepatitis C Worldwide 350 million infected 170 million infected United States 1 million infected 4 million infected Vertical transmission Mother to neonate Chronic hepatitis Rare - Horizontal transmission IV drug use, parenteral, sexual Recovery IV drug use, parenteral, sexual Chronic hepatitis Vaccine Yes No
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Molecular virology Feature HBV HCV Structure 42 nm enveloped partially dsDNA 50 nm enveloped +stranded RNA Family Hepadnaviridae Flaviviridae Receptor Unknown Includes CD81 Mutation rate Low (10 -5 /base) High (10 -3 /base) Genotypes 8; low divergence 6 with >50 subtypes
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Image removed for copyright reasons. Source: Figure 1 in Rehermann, B., and M. Nascimbeni. "Immunology of hepatitis B virus and hepatitis C virus infection." Nature Review Immunology 5, no. 3 (2005).
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HBV molecular virology • Relaxed circular 3.2-kb genome – Full-length negative strand, 5´ viral RT – Partial positive strand, 5´ oligoribonucleotide • cccDNA template for transcription of 4 viral RNAs in nucleus – Exported to cytoplasm and translated – Longest RNA also serves as template for HBV replication in nucleocapsids in the cytoplasm – Some DNA and nucleocapsids return to nucleus – Others bud into ER & are secreted via golgi
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This note was uploaded on 11/11/2011 for the course BIO 20.410j taught by Professor Rogerd.kamm during the Spring '03 term at MIT.

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hepat_virus_immu - Hepatitis virus immunity Mar 9, 2005...

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