immunity

Immunity - Immunity Robbins and Cotran Chapter 6 pp 193-240 Tysabri Recall Batters Biotechs Peter Kang 03.04.05 The outlook for the biotech sector

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Unformatted text preview: Immunity Robbins and Cotran Chapter 6 pp. 193-240 Tysabri Recall Batters Biotechs Peter Kang , 03.04.05 The outlook for the biotech sector suddenly became very bleak this week as shares of Biogen Idec tanked after the company halted sales of its Tysabri multiple sclerosis drug, which was deemed by a bevy of Street pundits as a blockbuster drug. The American Stock Exchange Pharmaceutical Index (DRG) logged another modest gain of 1.2% this week, while the Nasdaq Biotechnology Index (NBI) plunged 6.2%. Innate immunity Figure removed for copyright reasons. Source: Box 6-1 B in [RC] Kumar, V., A. K. Abbas, and N. Fausto. Robbins and Cotran Pathologic Basis of Disease , 7th ed. Philadelphia PA: Elsevier, 2005. ISBN: 0721601871. • Present before infection • Evolved to recognize microbes • Epithelial barriers, phagocytes, natural killer (NK) cells, and plasma proteins (including complement) Adaptive immunity Figure removed for copyright reasons. Source: Figure 6-2 in [RC] T cells • T cell receptor (TCR) rearrangement allows for antigen binding • 95% αβ TCR – 60% CD4+ – 30% CD8+ • 2 signals for activation – TCR + CD28 Figure removed for copyright reasons. Source: Figure 6-4 B in [RC] Figure by MIT OCW. "Variable" Segments "Diversity" Segments "Joining" Segments "Constant" Region V(D)J Recombination V-J Recombination Ig/T-cell Receptor mRNA 5' 3' V-DJ Recombination Transcription, Splicing B cells...
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This note was uploaded on 11/11/2011 for the course BIO 20.410j taught by Professor Rogerd.kamm during the Spring '03 term at MIT.

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Immunity - Immunity Robbins and Cotran Chapter 6 pp 193-240 Tysabri Recall Batters Biotechs Peter Kang 03.04.05 The outlook for the biotech sector

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