infect_disease

infect_disease - Infectious diseases Mar 30, 2005 Robbins...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
Infectious diseases Mar 30, 2005 Robbins and Cotran Chapter 7 pp. 343-411
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Tumor immunity • Immune surveillance – Cancer immunoediting • Tumor-specific antigens • Tumor-associated antigens • Anti-tumor effector mechanisms –CTL –NK ce l
Background image of page 2
Examples Oncogene products: mutated RAS, Bcr/Abl fusion proteins Normal self proteins Mutated self protein Overexpressed or aberrantly expressed self protein Oncogenic virus Product of oncogene or mutated tumor suppressor gene MHC Class I CD8+ CTL CD8+ CTL Virus antigen-specific CD8+ CTL No T cell response Tumor suppressor gene products: mutated p53 protein Overexpressed: tyrosinase, gp100, MART in melanomas Aberrantly expressed: cancer-testis antigens (MAGE, BAGE) Various mutant proteins in carcinogen, or radiation, induced animal tumors; various mutated proteins in melanomas Human papilloma virus E6, E7 proteins in cervical carcinoma: EBNA proteins in EBV induced lymphoma T cell T cell T cell T cell T cell Normal host cell displaying multiple MHC-associated self antigens Tumor cells expressing different types of tumor antigens Figure by MIT OCW.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Immuno- suppressive cytokines (e.g., TGF- β ) T cell recognition of tumor antigen leading to T cell activation Lack of T cell recognition of tumor Lack of T cell recognition of tumor Inhibition of T cell activation T cell T cell T cell Anti-tumor immunity Immune evasion by tumors Tumor cell Tumor antigen T cell specific for tumor antigen T cell MHC molecule Antigen-loss variant of tumor cell Failure to produce tumor antigen Mutations in MHC genes or genes needed for antigen processing Production of immuno-suppressive protein Class I MHC-deficient tumor cell Figure by MIT OCW.
Background image of page 4
Koch’s postulates 1) The organism is found in lesions of the disease 2) The organism can be isolated as single colonies on solid media 3) Inoculation of the organism causes lesions in experimental animals 4) The organism can be recovered from the experimental animal
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Toxin Terminology Exotoxin = protein toxins of bacteria, in contrast to endotoxin (LPS) – Not all exotoxins are secreted; some accumulate inside the bacterium and are released by bacterial lysis Cytotoxin = target a wide range of cell types, in contrast to neurotoxins , leukotoxins , hepatotoxins , cardiotoxins
Background image of page 6
More Toxin Terminology • Toxins can be named for the bacterial species that produce them, such as
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 36

infect_disease - Infectious diseases Mar 30, 2005 Robbins...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online