lec_25_slides

lec_25_slides - Cell Adhesion Structural Integrity External...

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Cell Adhesion • Structural Integrity • External Sensing •M igrat ion • Regulation of Transport • Communication
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Overview of the types of molecules that bind cells to each other and to the extracellular matrix
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Cell adhesion molecules and their characteristics Family Location and/or Ligands Comments function recognized integrins focal adhesions, (E) fibronectin, relatively low hemi-desmosomes, leukocy te collagen, laminin, immunoglobulins, affinities ( K D ~ 10 -6 -10 -8 ("spreading") (I) actin filaments mol/liter) adhesion, primarily cell-matrix adhesion but also in some cell-cell adhesions selectins circulating cells and carbohydrates require Ca 2+ endothelial cells, "rolling" adhesion Ig superfamily important in integrins, (immunoglobulin) cadherens immune response adherens junctions, homophillic (E) homophillic, require Ca 2+ desmosomes (I) actin filaments, intermediate filaments RD Kamm 2003
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Adhesion complexes Junction type Function Extracellular or
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lec_25_slides - Cell Adhesion Structural Integrity External...

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