lec14b_cell_atch - Harvard-MIT Division of Health Sciences...

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Unformatted text preview: Harvard-MIT Division of Health Sciences and Technology HST.523J: Cell-Matrix Mechanics Prof. Ioannis Yannas Macroscopic forces generated by cell-matrix interactions I. Cells generate forces after becoming attached to a matrix. II. How do cells attach to a matrix? III. Cell-matrix interactions control the spontaneous closure of wounds in organs. IV. What happens when wound closure occurs by induced regeneration? Integrin Superfamily INTEGRINS LIGANDS β1 Family α1β1 Fibrillar collagen, laminin α2β1 Fibrillar collagen, laminin α3β1 Fibronectin (RGD), laminin-5, entactin, denatured collagens α4β1 Fibronectin (LEDV), VCAM-1 α5β1 Fibronectin (RGD) α6β1 α7β1 Laminin Laminin α8β1 Fibronectin, vitronectin α9β1 Tenascin αv Family αvβ1 Fibronectin (RGD), vitronectin αvβ3 Vitronectin (RGD), fibronectin, fibrinogen, von Willebrand factor, thrombospondin, denatured collagen αvβ5 Fibronectin (RGD), vitronectin αvβ6 Fibronetcin, tenascin Other ECM Integrins αIIbβ3 α6β4 Same as αvβ3 Laminin β2 Family αMβ2 ICAM-1, iC3b, fibrinogen, factor X αLβ2 ICAM-1, 2, and 3 αxβ2 iC3b, fibrinogen Table by MIT OCW. After Clark, 1996. Figures removed for copyright reasons. See Figures 3 through 11 in Sethi K.K., I.V. Yannas, V. Mudera, M. Eastwood, C. McFarland, and R.A. Brown. “Evidence for sequential utilization of fibronectin, vitronectin, and collagen during fibroblast-mediated collagen contraction.” Wound Repair Regen. 2002 NovDec;10(6):397-408. Available in full-text version at PubMed (http://www.pubmed.org). ...
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lec14b_cell_atch - Harvard-MIT Division of Health Sciences...

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