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Unformatted text preview: Harvard-MIT Division of Health Sciences and Technology
HST.523J: Cell-Matrix Mechanics
Prof. Ioannis Yannas Macroscopic forces generated
by cell-matrix interactions
I. Cells generate forces after becoming
attached to a matrix.
II. How do cells attach to a matrix?
III. Cell-matrix interactions control the
spontaneous closure of wounds in
IV. What happens when wound closure
occurs by induced regeneration? Integrin Superfamily
INTEGRINS LIGANDS β1 Family
α1β1 Fibrillar collagen, laminin α2β1 Fibrillar collagen, laminin α3β1 Fibronectin (RGD), laminin-5, entactin,
denatured collagens α4β1 Fibronectin (LEDV), VCAM-1 α5β1 Fibronectin (RGD) α6β1
Laminin α8β1 Fibronectin, vitronectin α9β1 Tenascin αv Family
αvβ1 Fibronectin (RGD), vitronectin αvβ3 Vitronectin (RGD), fibronectin, fibrinogen, von
Willebrand factor, thrombospondin, denatured collagen αvβ5 Fibronectin (RGD), vitronectin αvβ6 Fibronetcin, tenascin Other ECM Integrins
α6β4 Same as αvβ3
Laminin β2 Family
αMβ2 ICAM-1, iC3b, fibrinogen, factor X αLβ2 ICAM-1, 2, and 3 αxβ2 iC3b, fibrinogen Table by MIT OCW. After Clark, 1996. Figures removed for copyright reasons.
See Figures 3 through 11 in Sethi K.K., I.V. Yannas, V. Mudera, M. Eastwood, C. McFarland,
and R.A. Brown. “Evidence for sequential utilization of fibronectin, vitronectin, and collagen
during fibroblast-mediated collagen contraction.” Wound Repair Regen. 2002 NovDec;10(6):397-408.
Available in full-text version at PubMed (http://www.pubmed.org). ...
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- Spring '03