MIT20_441JF09_hw1 - 2.79J/3.96J/20.441J/HST522J...

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2.79J/3.96J/20.441J/HST522J Biomaterials - Tissue Interactions Homework #1 1. Major problems with silicone breast implants (Fig. 1) are the thickening and contraction of the fibrous tissue (scar) capsule that forms around the device. Write the unit cell process(es) that are responsible for this thickening and contraction. Name possible regulators when they are known. 2. You have been hired by a firm to assist in the development of permanent ( i.e. , nonabsorbable) porous coatings to be applied to joint replacement prostheses to facilitate the fixation of the implant to bone. Bone is to form within the pores of a metal mesh material (Fig. 2) and thereby form an interlocking bond with the metal mesh coating of the prosthesis (“bone ingrowth “ for “biological fixation”). a. Which unit cell process(es) are responsible for bone ingrowth? No need to name the regulators here. b. Since the goal is to accelerate the bone ingrowth process your boss has suggested that certain regulators be incorporated into the coating in some way to be released after
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This note was uploaded on 11/11/2011 for the course BIO 20.410j taught by Professor Rogerd.kamm during the Spring '03 term at MIT.

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MIT20_441JF09_hw1 - 2.79J/3.96J/20.441J/HST522J...

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