MIT20_441JF09_hw5 - 2.79J/3.96J/20.441/HST522J Biomaterials...

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2.79J/3.96J/20.441/HST522J Biomaterials - Tissue Interactions Homework #5 1. A new company, Polycoat, offers a service to orthopedic companies in which they apply a polymer coating, 100 nm thick, to cobalt-chromium alloy prostheses. The coating contains calcium phosphate particles, 10 nm in diameter. The putative benefits of the coating are: 1) bone will bond to it and 2) water absorbed by the polymer will slowly dissolve the particles thereby releasing calcium, which will favorably affect nearby osteoblasts. You have been hired by an orthopedic company to help them analyze Polycoat-coated prostheses and review data from Polycoat. a. It is important to verify that the calcium phosphate particles are within 5 nm of the surface of the Polycoat coating. Given that you can employ only one of the following methods which would you chose and what would you measure: infrared spectroscopy, ESCA, X-ray diffraction? Explain. b.
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This note was uploaded on 11/11/2011 for the course BIO 20.410j taught by Professor Rogerd.kamm during the Spring '03 term at MIT.

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MIT20_441JF09_hw5 - 2.79J/3.96J/20.441/HST522J Biomaterials...

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