MIT20_441JF09_hw8

MIT20_441JF09_hw8 - 2.79J/3.96J/BEH.441/HST522J...

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2.79J/3.96J/BEH.441/HST522J Biomaterials - Tissue Interactions Homework #8 New hypothetical mechanism for tissue regeneration by a collagen-GAG scaffold It has recently been observed that TGF β 1 binds extensively on the large surface of a highly porous collagen-GAG scaffold. It will be assumed that bound TGFb1 is unavailable for regulation of cell function and that only unbound, or “free”, TGFb1 is involved in cell regulation. You are a researcher exploring the consequences of this new finding with the objective of using this fact in the design of new biomaterials-based approaches to regeneration. A. The researcher is familiar with data (“contraction-blocking data”) showing that collagen-GAG scaffolds block wound contraction most effectively when the average pore size lies between approximately 20 and 140 µm. See Fig. 1. Having conducted preliminary studies you have found out that the mass of bound TGF β 1, m , is directly proportional to the specific surface, σ , of a series of scaffolds. m
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MIT20_441JF09_hw8 - 2.79J/3.96J/BEH.441/HST522J...

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