notes20041008

notes20041008 - Analysis of the Interferon Network 8...

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Analysis of the Interferon Network 8 October 2004 Essigmann The Players: IFN: Interferon TF: Transcription Factor STAT: Signal Transducers and Activators of Transcription PK-R: RNA-activated protein kinase OAS: Oligo-A-Synthetase ADAR: Adenine Deaminase IRF: Interferon Regulatory Factor (TF, or component of a TF) IFN α R 1 IFN α R 2 cell surface IFN receptors IFN α R 3 JaK and TyK: Janus Kinases (JaK1, 2, 3; TyK2) ISRE: IFN-Stimulated Response Elements (DNA structures) RNaseL: endonuclease that cleaves double-stranded RNA of viral genomes Q: What happens when you get sick? A: You feel like crap. White blood cells work better at a higher temperature. Most pathogens are optimized for body temp. Feeling like crap = protein synthesis inhibition. Interferons do this. Properties of IFNs: a) cytokines: a protein that is produced by cell 1 and acts on cell 2 (and cell 1) b) proteins ~16-46 Kda (small) c) glycoproteins d) have disulfide bonds Classification of IFNs: a) by cell surface receptors which they bind b) by a diagnostic antibody to which they react (historically, antibodies were used as
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notes20041008 - Analysis of the Interferon Network 8...

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