pset2 - Problem Set 2 Issued: 02/23/06 Due: 03/02/06 100...

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20.462J/3.962J Issued: 02/23/06 Spring 2006 Due: 03/02/06 100 points total 1. From the reading for lecture 4 (Kumamoto et al., Nat. Biotech . 20 , 64-69 (2002)), we saw an example of how controlled release materials can be applied to create vaccines that attract immune cells to an immunization site. In this study, poly(ethylene-co-vinyl acetate) matrices were used. These are prepared by loading the polymer with a high amount of protein, such that the phase-separated protein forms a percolating network through the matrix, allowing for diffusion of the protein out of the sample once it is hydrated; as discussed in class, this leads to diffusion-based release much like a standard nondegradable matrix-based diffusion release. a. Based on your reading/analysis of the paper, cite what you think are the two most important limitations of the chosen matrix material for the given application, and explain your choices. b. Suggest an alternative material/release mechanism, and list two advantages and at least one potential issue with your alternative choice. Explain the advantages/issues you identify. 20.462J/3.962J PS 2
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pset2 - Problem Set 2 Issued: 02/23/06 Due: 03/02/06 100...

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