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pset5 - Problem Set 5 Issued Due 100 points total...

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Problem Set 5 20.462J/3.962J Issued: 04/04/06 Spring 2006 Due: 04/13/06 100 points total 1. (50 points) Compare and contrast a natural extracellular matrix based on collagen fibers with a synthetic matrix formed by a covalent PEG-based hydrogel containing –APGL- peptide linkages sensitive to the enzyme collagenase—answer in brief paragraphs: a. Structurally, do these gels present the same barrier to cell movement/migration? b. Which type of gel would you predict to be more rapidly degraded in vivo ? Why? c. In vivo , cells in either of these matrices will also be surrounded by other cells and ECM components. In what ways would you expect these matrices to differ in the way they mediate the interactions of cells with their surroundings? 20.462J/3.962J PS 5 1 of 2 9/4/06
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1. (50 points) One of the first studies of immobilized growth factor signaling utilized poly(ethylene oxide) (PEO) star polymers as anchors for the presentation of epidermal growth factor (EGF) on a solid surface (see schematic below). EGF receptor-expressing cells seeded on such a surface can bind the surface-bound EGF and receive stimulation to
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