viral_hep

viral_hep - Chronic viral hepatitis: Human Disease and...

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Chronic viral hepatitis: Human Disease and Animal Models Arlin Rogers MIT Division of Comparative Medicine BE.450 April 20, 2005
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Hepatitis viruses HAV: Acute gastroenteritis and/or hepatitis HBV : Acute or chronic hepatitis; significantly increases risk of hepatocellular carcinoma (HCC) HCV : Chronic hepatitis, cirrhosis and HCC HDV: delta agent; requires HBV for packaging HEV: Usually acute and self-limiting, but 20% mortality in pregnant women; HEV>HAV in India HFV: Single reported outbreak; agent unidentified HGV: Part of GB virus group; lymphotropic
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Hepatotropic Hepatitis Viruses of Humans Disease Virus Type/Old name Hepatitis A (HAV) RNA; hepatovirus/infectious hepatitis agent Sporadic or epidemic; acute only. Faecal-oral spread Hepatitis B (HBV) DNA; hepadnavirus/serum hepatitis agent; Australia antigen Acute or chronic, including hepatocellular carcinoma (HCC). Parenteral spread Hepatitis C (HCV) RNA; flavi- and pestivirus-like/ transfusion-associated NANB hepatitis virus Acute, often chronic, including HCC. Spread typically parenteral, but also sporadic Hepatitis D (HDV) RNA, defective virus/delta agent HBV needed for pathogenicity; increases severity of type B hepatitis Hepatitis E (HEV) RNA virus/enteric NANB hepatitis virus Sporadic or epidemic; probably acute disease only. Faecal-oral spread Others RNA; Flaviviridae , also known as GBV-C Paramyxovirus/syncytial giant-cell hepatitis Toga-virus Parvovirus B19 TT-virus Perhaps causes mild disease, but may not; often associated with HCV or HBV Reported association with aggressive hepatitis may be in doubt May be implicated in a fulminant type of hepatitis Implicated in fulminant hepatitis associated with aplastic anaemia in children Implicated in fulminant and post-transfusion hepatitis Figure by MIT OCW.
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Acute Classical (icteric) acute type Subclinical (anicteric) Cholestatic Fulminant Neonatal Atypical variants in immunocompromised patients # # Fibrosing cholestatic or cholestatic forms with more aggressive clinical presentations Carrier state chronic persistent hepatitis) Atypical variants in immunocompromised patients # Chronic Typical forms (formerly known as chronic active and Clinicopathological Syndromes of Viral Hepatitis Figure by MIT OCW.
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Acute viral hepatitis • Flu-like symptoms • Anorexia & nausea • ± Icterus (jaundice) – Yellow mucous membranes – More common in adult form Ç hepatocyte enzymes – ALT, AST • ± Biliary obstruction (cholestasis) –I t c h i n
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Fulminant hepatic necrosis (rare) • Very serious, often fatal complication • Indistinguishable from Figure removed for copyright reasons. toxic and idiosyncratic
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This note was uploaded on 11/11/2011 for the course BIO 20.410j taught by Professor Rogerd.kamm during the Spring '03 term at MIT.

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viral_hep - Chronic viral hepatitis: Human Disease and...

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