7_88_assign2 - Press, 2000. Of historical interest (not...

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MIT OpenCourseWare http://ocw.mit.edu 7.88J Protein Folding Problem Fall 2007 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms .
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5.48j/7.24j/7.88j/10.545j The Protein Folding Problem Handed out Session 3 2nd Assignment Required reading: 1. C. B. Anfinsen, E. Haber, M. Sela, and F. H. White, Jr. (1961) The Kinetics of Formation of Native Ribonuclease During Oxidation of the Reduced Polypeptide Chain. PNAS, 47: 1309- 1314. Download from link: http://www.jstor.org/stable/71349. 3. Glusker, Jenny Pickworth (2000) Crystalizing the Life of Dorothy Hodgkin. Chem.Eng.News , 78, 28-30. Download from link: http://pubs.acs.org/isubscribe/journals/cen/78/i27/html/7827book1.html This is a review of Dorothy Hodgkin: A Life by Georgina Ferry, Cold Spring Harbor Laboratory
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Unformatted text preview: Press, 2000. Of historical interest (not required) : Linus Pauling Nobel Prize Lectures [Download from link] 1954 Chemistry: Modern Structural Chemistry http://nobelprize.org/chemistry/laureates/1954/pauling-lecture.html 1962 Peace: Science and Peace http://nobelprize.org/peace/laureates/1962/pauling-lecture.html Assignment (Answers to be handed in Session 5 ): 1. Anfinsen et al present and discuss a series of possible models for the refolding pathways followed by the RNase chains in their experiments in Figure 1. Summarize their rationales for rejecting models A1, A2 and A3 on the basis of the figure 1 data. 2. Diagram with line drawings the known N > C helical orientations along the polypeptide chain for 4 helix bundles proteins. Are there classes of helix arrangements that have not been found? ________________________...
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This note was uploaded on 11/11/2011 for the course BIO 7.344 taught by Professor Bobsauer during the Spring '08 term at MIT.

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7_88_assign2 - Press, 2000. Of historical interest (not...

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