7_88_assign3

7_88_assign3 - many orientations. Do they all occur with...

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MIT OpenCourseWare http://ocw.mit.edu 7.88J Protein Folding Problem Fall 2007 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms .
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The Protein Folding Problem ‘07 Assignment 3 Session 5 Reading Branden and Tooze; Chapter 4: Alpha/beta Structures Chaper 5: Beta Structures, pp 67-80. These chapters are very clearly written, but densely packed with 3-D information. Give yourself additional time to examine and assimilate the images. Questions to answer (turn in Session 8): 1. Four beta strands or a pair of beta-hairpins can be packed into a sheet in
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Unformatted text preview: many orientations. Do they all occur with equal frequency among solved protein structures? How do the rare packings differ from the common ones? 2. Are the hydrogen bonding patterns between the strands of the jellyroll fold equivalent for all pairs of strands? If not, where do they differ? 3 Lesk and Chothia compared nine globin proteins of diverse sequence. What were their initial assumptions to explain the conserved three-dimensional structure? What did they find instead?...
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7_88_assign3 - many orientations. Do they all occur with...

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