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7_88_assign5 - MIT OpenCourseWare http/ocw.mit.edu 7.88J...

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MIT OpenCourseWare http://ocw.mit.edu 7.88J Protein Folding Problem Fall 2007 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms .
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The Protein Folding Problem ‘07 Assignment 5 Handed out during Session 10 Amino Acid Sequence Control of Alpha Helix Formation: Thus far in class, we have identified a number of interactions thought to be driving a sequence into an alpha helical conformation or stabilizing that conformation. The following papers identify intrahelical electrostatic interactions directing sequences into the alpha helical conformation, and helix-capping interactions at the beginnings and ends of helical stretches, controlling helicity in polypeptide chains destined for globular protein folds. Next week we will cover in class the Heptad repeat controlling helicity in coiled-coil proteins. Reading: Hand out: 1. Susan Marquesee and Robert L. Baldwin (1990) Alpha-helix formation by short peptides in water. In: Protein Folding: Deciphering the Second Half of the Genetic Code. (L. Gierasch & J.
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