7_340_3

7_340_3 - Under the Radar Screen: How Bugs Trick Our Immune...

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Marie-Eve Paquet and Gijsbert Grotenbreg Whitehead Institute for Biomedical Research Under the Radar Screen: How Bugs Trick Our Immune Defenses Session 3: Toll-like receptors (TLRs)
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Introduction to Toll-like Receptors (TLRs) Historical Background TLRs as the link between innate and adaptive immunity What kind of Pathogen Associated Molecular Patterns do TLRs recognize What’s known about TLR structure and activity The detailed signaling pathways which TLRs
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Introduction to Toll-like Receptors (TLRs) The discovery of the Toll-like receptors 1985: Christiane Nüsslein-Volhard identified Toll genes ( Toll = cool, weird in German ) in Drosophila melanogaster as gene important in embryogenesis in establishing the dorsal-ventral axis. 1989: Janeway predicts that our immune system uses PAMPs (pathogen-associated molecular patterns) as tools to identify molecules that would always be associated with infection. The concept that immune systems decide when to initiate a response based on the microbial nature of the molecules encountered became known as the pattern recognition hypothesis 1994: Nomura et al. described the first reported human Toll-like receptor
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This note was uploaded on 11/11/2011 for the course BIO 7.344 taught by Professor Bobsauer during the Spring '08 term at MIT.

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7_340_3 - Under the Radar Screen: How Bugs Trick Our Immune...

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