7_340_4

7_340_4 - Marie-Eve Paquet and Gijsbert Grotenbreg...

Info iconThis preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Marie-Eve Paquet and Gijsbert Grotenbreg Whitehead Institute for Biomedical Research Under the Radar Screen: How Bugs Trick Our Immune Defenses Session 4: Ubiquitination and the Proteasome In this session Paper 1. Identifies a ubiquitin-specific protease (DUB) in Herpes Simplex Virus 1 using activity-based probes, mass spectrometry and proteomic analysis Paper 2. Deals with the YopJ virulence factor of Yersinia, which is shown to act as DUB, using an NFkB dependent reporter assay and epitope-tagged Ub. The role of these viral and bacterial gene products in immune evasion through possible rescue from proteasomal degradation and inhibition of NFkB signaling will be discussed A Deubiquitinating Enzyme Encoded by HSV-1 Belongs to a Family of Cysteine Proteases that Is Conserved across the Family Herpesviridae Molecular Cell , 19 , pp547-557, (2005) Lisa M. Kattenhorn, Gregory A. Korbel, Benedikt M. Kessler, Eric Spooner, and Hidde L. Ploegh Paper 1 A. What does the inclusion of NEM prove in Fig. 1B in the paper?A....
View Full Document

This note was uploaded on 11/11/2011 for the course BIO 7.344 taught by Professor Bobsauer during the Spring '08 term at MIT.

Page1 / 6

7_340_4 - Marie-Eve Paquet and Gijsbert Grotenbreg...

This preview shows document pages 1 - 5. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online