7_340_5

7_340_5 - How Bugs Trick Our Immune Defenses Session 5 MHC...

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Marie-Eve Paquet and Gijsbert Grotenbreg Whitehead Institute for Biomedical Research Under the Radar Screen: How Bugs Trick Our Immune Defenses Session 5: MHC class I antigen presentation
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Human cytomegalovirus (HCMV) • CMV is a member of the herpesvirus family, which includes the herpes simplex viruses and the viruses that cause chicken pox (varicella-zoster virus) and infectious mononucleosis (Epstein-Barr virus) • Most common congenital (present at birth) infection in the United States. • Once CMV is in a person's body, it stays there for life • Most CMV infections are "silent” meaning they cause no signs or symptoms in an infected person.
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Reagents Anti HC: antibody that reacts with the MHC class I heavy chain, regardless of its association with b2m and peptide W632: antibody that reacts with folded/assembled MHC class I LLnL, CbzLLL, lactacystin: proteasome inhibitors. In the presence of these inhibitors, proteins that are targeted for degradation accumulate inside the
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7_340_5 - How Bugs Trick Our Immune Defenses Session 5 MHC...

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