7_340_6

7_340_6 - Under the Radar Screen: How Bugs Trick Our Immune...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
Marie-Eve Paquet and Gijsbert Grotenbreg Whitehead Institute for Biomedical Research Under the Radar Screen: How Bugs Trick Our Immune Defenses Session 06: Major Histocompatiblity (MHC) class II antigen presentation
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
In this session Paper 1. Attack on the T-cell: Identifies the Nef-gene product of HIV to downregulate surface expression of CD4 (without transcriptional or translational defects) via a pathway different from normal downregulation after T-cell activation (which is Serine phosphorylation dependent) Paper 2. Attack on the Antigen Presenting Cell (APC): Identifies the Vpx-gene product of HIV to interact with the Invariant Chain (using cell-free, transfected and infected cells).
Background image of page 2
Human immunodeficiency virus (HIV) Biology Viral Entry: Macrophages and CD4+ T cells are targeted by HIV because of glycoproteins on the HIV surface (gp160 Æ gp120, gp41) which are capable of binding the CD4 co-receptor and chemokine receptors. Ultimately, this leads to membrane fusion and capsid entry Replication and transcription: Viral RNA transcription into DNA (error prone = drug resistance) Viral DNA gets integrated into the host genome Here, the virus can be dormant Transcription factor dependent activation generates mRNA. (T-cell activation (NFkB) leads to killing of T-cell !!)
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 11/11/2011 for the course BIO 7.344 taught by Professor Bobsauer during the Spring '08 term at MIT.

Page1 / 8

7_340_6 - Under the Radar Screen: How Bugs Trick Our Immune...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online