7_340_8

7_340_8 - Under the Radar Screen: How Bugs Trick Our Immune...

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Marie-Eve Paquet and Gijsbert Grotenbreg Whitehead Institute for Biomedical Research Under the Radar Screen: How Bugs Trick Our Immune Defenses Session 8: Apoptosis
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Myxoma virus • Poxvirus • Infects rabbits and causes myxomatosis (skin lesions, swelling of the head, lumps on paws, ears and nose) • Can be lethal but in time, rabbit populations can develop an immunity to the virus • Was spread intentionally in Australia as an attempt to control the population of European rabbits that had grown out of proportion since their introduction in the 1950s
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Epstein-Barr virus •H e r p e s v i r u s • One of the most common human virus, it causes Mononucleosis or B cell lymphomas (has growth transforming capacity)
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Apoptosis • Deliberate death of a cell, aka programmed cell death. Opposed to Necrosis which is cell death resulting from an injury. • Can be necessary during certain phases of development and can provide a source of antigens to APCs. • Involves a cascade of biochemical events. • Mitochondria: Key organelle in apoptosis. It controls the release of cytochrome C into the cytosol through the formation of pores. • Role of BCL-2: BCL2 is the prototype for a family of genes. They govern mitochondrial outer membrane permeabilisation (MOMP) and can be either pro-apoptotic (including Bax, Bak and Bok) or anti-apoptotic (including Bcl-2, Bcl-xL, and Bcl-w). They can induce or block the release of cytochrome C into the
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7_340_8 - Under the Radar Screen: How Bugs Trick Our Immune...

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