7_340_10

7_340_10 - How Bugs Trick Our Immune Defenses Session 10:...

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Marie-Eve Paquet and Gijsbert Grotenbreg Whitehead Institute for Biomedical Research Under the Radar Screen: How Bugs Trick Our Immune Defenses Session 10: Antimicrobial peptides
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Antimicrobial Peptides: Structure and Function Cationic Antimicrobial Peptides (CAPs) Small peptides of 8-30 amino acid residues Both positively charged and lipophilic amino acid residues Defined structure like α -helix or β -sheet Creates holes in membrane which kills the target cell
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Recognition of Antimicrobial Peptides by a Bacterial Sensor Kinase Cell , 122 , pp461–472, (2005) Martin W. Bader, Sarah Sanowar, Margaret E. Daley, Anna R. Schneider, Uhnsoo Cho, Wenqing Xu, Rachel E. Klevit, Hervé Le Moual, and Samuel I. Miller Paper 1
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Questions • Which CAPs are used in the paper and what do we know about them? • In Fig.1, how is the assay performed and what are Miller units ? • For Fig.3, how have the authors assessed the topology of the proteins in membrane vesicles ? • In Fig.4, what does the experiment tell you and how does the Fe
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7_340_10 - How Bugs Trick Our Immune Defenses Session 10:...

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