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Unformatted text preview: transcription." Nat Rev Mol Cell Biol. 2003 Mar;4(3):192-201. The ubiquitin (Ub)–proteasome system regulates transcription at numerous levels. a | Interactions of an activator with the general transcriptional machinery (green) functions to b | recruit ubiquitin ligase(s) to the site of transcription and ubiquitylates many factors, including the activator, RNA polymerase II (pol II) and histones. c | These ubiquitylation events in turn recruit the 26S proteasome, which d | simultaneously destroys the activator and promotes elongation of transcription by pol II. Importantly, this proposed mechanism limits uncontrolled transcription in two ways — by destroying the activator at each cycle of promoter 'firing' and by ensuring that interactions between pol II and the proteasome are made in an activator- and promoter-dependent manner....
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