l4_notes

L4_notes - Summary Lecture 3 Image by MIT OCW L4 Cooperativity introduction phage model phage model(Hasty et al as example for applying mass action

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Summary Lecture 3 Image by MIT OCW.
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L4: Cooperativity & introduction λ phage model λ phage model (Hasty et al.) as example for applying mass action law. A d k X nX P 2 DX t k P 2 DX 2 DX 2 DX 4 K 2 X 2 DX * 2 DX 3 K 2 X D 2 DX 2 K 2 X D 2 X 1 K 2X ⎯→ + + ⎯→ + ⎯→ + ⎯→ + ⎯→ + ⎯→ OR2 OR3 λλ λλ λ λ OR2 OR3 λλ OR2 OR3 λλ λλ K 1 K 2 fast slow most important step in modeling !! most important step in modeling !! biology math
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2 K 1 K r d k γ r T d 0 p t nk α 2 K 4 K 2 σ 2 K 3 K 1 σ 1 γ x 4 x 2 σ 2 )x 1 σ (1 1 2 α x dt dx = = = = + + + + = A d k X nX P 2 DX t k P 2 DX 2 DX 2 DX 4 K 2 X 2 DX * 2 DX 3 K 2 X D 2 DX 2 K 2 X D 2 X 1 K 2X ⎯→ + + ⎯→ + ⎯→ + ⎯→ + ⎯→ + ⎯→ relative binding constants ~ synthesis/basal rate ~ degradation/basal rate mass action choose elegant (dimensionless, relative) variables !
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graphical stability analysis
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How to experimentally verify these ideas ?
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This note was uploaded on 11/11/2011 for the course BIO 7.344 taught by Professor Bobsauer during the Spring '08 term at MIT.

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L4_notes - Summary Lecture 3 Image by MIT OCW L4 Cooperativity introduction phage model phage model(Hasty et al as example for applying mass action

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