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l8_notes - Fine tuned model for perfect adaptation Spiro et...

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‘Fine tuned model for perfect adaptation’ Spiro et al. PNAS 94 , 7263-7268 (1997) A model of excitation and adaptation in bacterial chemotaxis
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key player: Tar-CheA-CheW complex Copyright (1997) National Academy of Sciences, U. S. A. Figure 1 of Spiro, P. A., J. S. Parkinson, and H. G. Othmer. Proc Natl Acad Sci U S A 94, no. 14 ( Jul 8 , 1997) : 7263-8. " A model of excitation and adaptation in bacterial chemotaxis. "
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assumptions: 1. Tar is only receptor type, CheW and CheA always bound to Tar 2. Methylation occurs in specific order 3. Consider only 3 highest methylation states 4. Only CheB p demethylates 5. Phoshorylation of CheA does not affect ligand (un)binding 6. Tar-CheR binding does not affect ligand un(binding) and phosphorylation of CheA 7. CheZ is not regulated 8. Phosphotransfer from complex to CheY or CheB is not affected by occupancy or methylation state.
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fast slow i n t e r m d a Copyright (1997) National Academy of Sciences, U. S. A. Figure
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l8_notes - Fine tuned model for perfect adaptation Spiro et...

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