l9_notes

l9_notes - Wrapping up E. coli Chemotaxis (L7 & L8)...

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Main points of last 2 lectures: L7: Biological background what is the function of the individual molecules ? L8: modeling of all possible chemotactic reactions why doesn’t this model reproduce experimentally observed perfect adaptation ? L8-9 : strip down full model to essentials based on assumptions that are experimentally justified (or sometimes not) reduction 1
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100, no. 23 (Nov 11, 2003): 13259-63. Copyright (2003) National Academy of Sciences, U. S. A. Figure 1A in Mittal, N., E. O. Budrene, M. P. Brenner, and A. Van Oudenaarden. "Motility of Escherichia coli cells in clusters formed by chemotactic aggregation." Proc Natl Acad Sci U S A .
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Absence of chemical attractant 4 Image by MIT OCW. Tumble Run
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Presence of chemical attractant 5 Image by MIT OCW. Tumble Chemical Gradient Sensed in a Temporal Manner Run Attractant
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6 Figure 1 of Spiro, P. A., J. S. Parkinson, and H. G. Othmer. Proc Natl Acad Sci U S A 94, no. 14 (Jul 8, 1997): 7263-8. "A model of excitation and adaptation in bacterial chemotaxis." key player: Tar-CheA-CheW complex Copyright (1997) National Academy of Sciences, U. S. A.
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fast slow i n t e r m d a Copyright (1997) National Academy of Sciences, U. S. A. Figure 2 of Spiro, P. A., J. S. Parkinson, and H. G. Othmer. Proc Natl Acad Sci U S A 94, no. 14 (Jul 8, 1997): 7263-8. "A model of excitation and adaptation in bacterial chemotaxis."
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T 2 LT 2 T 3 LT 3 T 2p LT 2p T 3p LT 3p k eff1 (L) k eff2 (L) k eff3 (L) k eff4 (L) k eff3 (L) k eff4 (L) k pt k pt First reduction α 1- α [3] [2] [3] α + in steady state: 8 (L) eff2 α k (L) eff1 α )k (1 phos k + =
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l9_notes - Wrapping up E. coli Chemotaxis (L7 & L8)...

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