lec6illustrated

lec6illustrated - MIT OpenCourseWare http:/ocw.mit.edu...

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MIT OpenCourseWare http://ocw.mit.edu 7.88J Protein Folding Problem Fall 2007 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms .
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Coiled Coils± 7.88J Protein Folding Prof. David Gossard September 24, 2003
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PDB Acknowledgements The Protein Data Bank (PDB - http://www.pdb.org/ ) is the single worldwide repository for the processing and distribution of 3-D biological macromolecular structure data. Berman, H. M., J. Westbrook, Z. Feng, G. Gilliland, T. N. Bhat, H.Weissig, I. N.Shindyalov, and P. E.Bourne. “The Protein Data Bank.” Nucleic Acids Research 28 (2000): 235-242. (PDB Advisory Notice on using materials available in the archive: http://www.pdb.org/pdb/static.do?p=general_information/about_ pdb/pdb_advisory.html ) PDB molecules and citations used in the “Coiled Coils” Lecture Notes for 7.88J - Protein Folding PDB ID: 2ZTA JRNL reference: O'Shea, E. K., J. K. Klemm, P. S. Kim., and T. Alber. “X-ray structure of the GCN4 leucine zipper, a two- stranded, parallel coiled coil.” Science 254 (1991): 539. Pages: 3 (“Outline”), 14-15 (“GCN4 Leucine Zipper”)
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Outline± • Review Key Features of Coiled Coils± • Examine a Particular Example – GCN4 Leucine Zipper (2ZTA)
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C Coiled Coils± Left-handed spiral of right-handed helices± • May be parallel N N C C or anti-parallel N C N
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2-Stranded Coiled Coils± •G C N 4 •² Tropomyosin •² Intermediate filament protein •L a m i n •² M-protein •² Paramyosin •M y o s i
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This note was uploaded on 11/11/2011 for the course BIO 7.344 taught by Professor Bobsauer during the Spring '08 term at MIT.

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lec6illustrated - MIT OpenCourseWare http:/ocw.mit.edu...

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