lecture_5_Notes

lecture_5_Notes - Synaptic Plasticity II Lecture#5...

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Synaptic Plasticity II Lecture #5 Expression of Long Term Plasticity () ( [] sr ch r o o SNp q qN VVpN T Ca p NMDAR γ ∝− ±± ) Presynaptic Mechanisms – The concentration of transmitters in synaptic cleft o probability of release o filling of vesicle o diffusion of transmitters in synaptic cleft o Retrograde Messages 1. NO, CO, Neurotropins Postsynaptic Mechanisms – The number and properties of postsynaptic receptors insertion of new receptor gating of existing receptor Number of Synapses Synapse formation or elimination Signas Transducation Pathways that Transfer Local Ca++ Influx into Long-Term Synaptic Modification Protein Kinases and Phosphatases Regulation of gene expression Mechanisms of Protein Synthesis-Dependent Long Term Synaptic Plasticity Long-term expression of synaptic plasticity requires protein synthesis How to achieve input specificity?
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Background Reading (Engert et al., 2002; Lichtman and Colman, 2000; Malinow and Malenka, 2002; Martin et al., 2000; Poo, 2001; Renger et al., 2001; Trachtenberg et al., 2002)
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This note was uploaded on 11/11/2011 for the course BIO 7.344 taught by Professor Bobsauer during the Spring '08 term at MIT.

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lecture_5_Notes - Synaptic Plasticity II Lecture#5...

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