Lecture2

Lecture2 - Long-Lasting Potentiation of Synaptic...

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Scientific reading and writing and learning mechanisms of simple invertebrates. Session 2
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Cookie assignment
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Questions we ask ourselves when reading a paper • What was the question? • How did the authors try to answer it? • Did they succeed in answering it? • What are the implications of this work?
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Today’s papers
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Neuronal excitability In Out K – 400 Na – 50 Cl – 52 Charged proteins - 385 20 440 560 E=58/z*log [Xo]/[Xi] -75 +55 -60 Vm=(ENa x gNa) + (Ek x gK) + (ECl x gCl) gNa + gK + gCl
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Figure by MIT OpenCourseWare
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Neuronal transmission Image courtesy of Mariana Ruiz Villarreal
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Neuronal plasticity Input 1 Input 2 Output
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Bliss and Lomo – the discovery of LTP Images removed due to copyright considerations. See Figures 1 and 4 in Bliss, T. and T. Lomo. “
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Unformatted text preview: Long-Lasting Potentiation of Synaptic Transmission in the Dentate Area of the Anaesthetized Rabbit Following Stimulation of the Perforant Path . J. Physiol. 232 (1973): 331-356. Protein synthesis Image removed for copyright considerations. See Figure A.6. in Appendix A: Early Development . In Stem Cell Information . Bethesda, MD: National Institutes of Health, U.S. Department of Health and Human Services, 2006. Questions for next week Schwartzkroin and Wester How is the specificity of the input demonstrated? Stanton and Sarvey What is the difference between Emetine and Cycloheximide as demonstrated by this paper?...
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Lecture2 - Long-Lasting Potentiation of Synaptic...

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