Lecture4

Lecture4 - • Calcium can enter the cell through other...

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Molecular mechanisms underlying LTP.
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Sodium channels and refractory periods Figure by MIT OpenCourseWare
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Questions we ask ourselves when reading a paper • What was the question? • How did the authors try to answer it? • Did they succeed in answering it? (necessary and sufficient). • What are the implications of this work?
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Today’s papers
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Post synaptic density synapses.clm.utexas.edu/ anatomy/chemical/psd.gif Image courtesy of Mariana Ruiz ( http://commons.wikimedia.org/ )
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LTP mechanics I Figure by MIT OpenCourseWare
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LTP mechanics II Figure by MIT OpenCourseWare
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Complicating the picture
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Unformatted text preview: • Calcium can enter the cell through other channels. • Calcium entering the cell can things other than LTP. Non NMDA LTP . Adapted from Kamsler, A. and M. Segal. “Hydrogen Peroxide Modulation of Synaptic Plasticity.” J. Neurosci. 23 (2003): 269-276 8 arm task RM – reference memory – long term WM – working memory – short term Questions for next week • Dudek and Bear – what are the characteristics shared by LTP and LTD? • Borroni et al – in figure 5 – what is represented by the dark bars in panel A? and what in panel B?...
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This note was uploaded on 11/11/2011 for the course BIO 7.344 taught by Professor Bobsauer during the Spring '08 term at MIT.

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Lecture4 - • Calcium can enter the cell through other...

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