Lecture10

Lecture10 - Synaptic tagging. Tagging Input 1 Input 2...

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Synaptic tagging.
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Tagging Input 1 Input 2 Output
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How do you show that a ‘tag’ molecule exists?
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Cross tagging experiments were designed to show that there is a ‘tag’. Setting a tag Creating PRPs – plasticity related proteins ‘capturing’ PRPs
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Induction Setting a tag Creating PRPs – plasticity related proteins ‘capturing’ PRPs
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Maintenance Setting a tag Creating PRPs – plasticity related proteins ‘capturing’ PRPs
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Today’s papers
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Assignment • This week’s papers present a theoretical framework called ‘synaptic tagging’ which was created for understanding molecular events underlying memory. • One of the issues addressed by ‘tagging’ is: How does the molecular signal being amplified in the nucleus know which synapse to go back to?
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Assignment (2) • Write a full and detailed description of the events underlying LTP as we have discussed them throughout the course. • This should take about a full page.
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This note was uploaded on 11/11/2011 for the course BIO 7.344 taught by Professor Bobsauer during the Spring '08 term at MIT.

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Lecture10 - Synaptic tagging. Tagging Input 1 Input 2...

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