mdtm_2003_answrs - 9.09J/7.29J Cellular Neurobiology Spring...

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7.29 J 9.09 Cellular Neurobiology Answers to 2003 Midterm Test Question 1. a) M Channel . Potassium channel that is closed (indirectly by second-messenger system) consequent to binding of acetylcholine to muscarinic receptor or LHRH to LHRH receptor on sympathetic ganglion cells. Closing is responsible for slow EPSP and late-slow EPSP. b)Xenopus. African clawed toad. Has a big oocyte that is used for testing of cloned genes for ion channels. Inject cDNA from the clone, patch-clamp the oocyte membrane and look for new conductance channels. c) Yeast mutants. Yeast sec mutants (involved in Golgi vesicle trafficking) used to clone sec genes. Sequence of these genes corresponds to many vesicle proteins involved in calcium-evoked neurotransmitter release. d) Freeze Fracture. A technique for visualization of biological material by electron microscopy. Fracture lines go between layers of biological membranes. Used by Heuser et al. to visualize synaptic vesicle fusion at neuromuscular junction. e) Saltatory. Describes “jumping” conduction of action potential from node to node of Ranvier in meyelinated axons. f) Cyclic AMP dependent kinase. Closes S-type potassium channel in Aplysia . Involved in synaptic facilitation, sensitization, and differential conditioning of the gill, mantle, and siphon withdrawal reflex(es) in that animal. g) Schaeffer Collateral. An a xon to presynaptic terminals of synapses in CA1 region of hippocampus. These synapses are studied for long-term potentiation (LTP). h) Tetraethylammonium. A blocker of potassium channels in squid axon. Used in pharmacological dissection of sodium and potassium currents in action potential (and ultimate resolution of g K and g Na kinetics). i) Vagusstoff.
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This note was uploaded on 11/11/2011 for the course BIO 7.344 taught by Professor Bobsauer during the Spring '08 term at MIT.

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mdtm_2003_answrs - 9.09J/7.29J Cellular Neurobiology Spring...

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