antmy_parkinson

antmy_parkinson - Anatomy in Parkinsons What can we see...

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Anatomy in Parkinson’s: What can we see with MRI?
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Volume & Thickness
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Substantia Nigra: Inversion Recovery SN notoriously difficult to visualize on conventional T1- weighted images Techniques employed (with varying success) Pulse sequences sensitive to iron deposition Width of SNpc on T2-weighted images Indirect measures of DA in striatum (PET & SPECT) No ideal MRI-based method Inversion recovery (Hutchinson & Raff, 1999; 2000) One pulse to suppress white matter another to suppress gray matter Signal change seen in both images Use ratio of images to increase sensitivity ROI-based analyses Æ within Ss ratio of lateral:medial signal intensity May be useful for staging of disease or detecting
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