antmy_parkinson

antmy_parkinson - Anatomy in Parkinson’s: What can we see...

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Unformatted text preview: Anatomy in Parkinson’s: What can we see with MRI? Volume & Thickness Substantia Nigra: Inversion Recovery • SN notoriously difficult to visualize on conventional T1weighted images • Techniques employed (with varying success) – – – – Pulse sequences sensitive to iron deposition Width of SNpc on T2-weighted images Indirect measures of DA in striatum (PET & SPECT) No ideal MRI-based method • Inversion recovery (Hutchinson & Raff, 1999; 2000) – – – – One pulse to suppress white matter another to suppress gray matter Signal change seen in both images Use ratio of images to increase sensitivity ROI-based analyses within Ss ratio of lateral:medial signal intensity • May be useful for staging of disease or detecting presymtomatic cases Area of SN in PD A re a ( m m 2 ) 60 50 PD Control 40 40 60 80 Age Figure by MIT OCW. Oikawa et al (2002) Substantia Inominata • Region that includes nucleus basalis of Meynert (cholinergic) • Visible on T2-W MRI • Atrophic in Alzheimer’s • Thickness measured in PD – Controls, non-demented PD, & PD w/ mild dementia (MMSE < 23) Correlations with SI Thickness 3.5 3.1 (P < 0.05, r = 0.36) Thickness of SI (mm) PD Control PD (r = -0.66, P < 0.01) Control (r = -0.37, NS) Age MMSE 3.1 2.7 2.7 2.3 2.3 1.9 1.5 18 1.9 22 26 30 1.5 40 50 60 70 80 Figure by MIT OCW. Oikawa et al (2004) ...
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This note was uploaded on 11/11/2011 for the course BIO 9.07 taught by Professor Ruthrosenholtz during the Spring '04 term at MIT.

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antmy_parkinson - Anatomy in Parkinson’s: What can we see...

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