lec3 - The visual and oculomotor systems Peter H. Schiller,...

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The visual and oculomotor systems Peter H. Schiller, year 2006 The ON and OFF Channels
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Questions: 1. How are the ON and OFF channels created for the cones? 2. How are the ON and OFF channels created for the rods? 3. How do the ON and OFF channels contribute to the center-surround organization of RGCs? 4. What role do the ON and OFF channels play in giving rise to the trasforms seen in visual cortex? 5. Why did the ON and OFF channels arise in evolution?
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The neural responses of the ON and OFF retinal ganglion cells
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Recording Methods: Stimulation Methods: electrode in nerve electrode in eye direct light fiber hook optic nerve ON cell OFF cell ON/OFF cell on time
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The receptive fields of three major classes of retinal ganglion cells OFF inhibition ON inhibition ON/ OFF inhibition
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Action potentials discharged by an ON and an OFF retinal ganglion cell Stimulation confined to receptive field center ON cell OFF cell Stimulation of the eentire receptive field ON cell OFF cell light spot dark spot light stimulation condition time
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Anatomy of the ON and OFF retinal ganglion cells
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Intracellular recording and labeling method dye filled microelectrode retinal ganglion cell
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The dendritic arborization pattern of ON and OFF retinal ganglion cells c c f i a b Ga Gb IPL OFF Organization of cone bipolar cells and ganglion cells in the IPL of the cat retina. Flat cone bipolar cells (f) have axon terminals ending in sublamina a contacting the dendrites of a-type ganglion cells (Ga). Invaginating cone bipolar cells (i) have axon terminals which ramify lower in the IPL in sublamina b where they contact b-type ganglion cell dendrites (Gb). Ganglion cells of various morphologies branch either in sublamina a or sublamina b; these prove to be off-center and on-center, respectively, c, cones. Figure by MIT OCW.
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Overview of retinal connections
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Photoreceptor basics: 1. All photoreceptors hyperpolarize to light. 2. Depolarization of the photoreceptor releases glutamate. 3. Photon absorption by the photopigment results in isomerization of the chromophore from 11-cis to all-trans.
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This note was uploaded on 11/11/2011 for the course BIO 9.07 taught by Professor Ruthrosenholtz during the Spring '04 term at MIT.

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lec3 - The visual and oculomotor systems Peter H. Schiller,...

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