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lecture_4_Notes - • The correlation between the...

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Synaptic Plasticity I Lecture #4 Experimental approaches to determine the strength of synaptic connections Potentiation of synaptic transmission (PTP, STP, LTP, L-LTP) Induction of LTD Spike timing dependent plasticity (Bi and Poo, 1998) Properties of LTP Cooperativity Associativity Input Specificity Mechanisms of LTP induction The role of NMDA receptor activation NMDA receptor act as molecular coincident detector The role of Ca++ influx
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Unformatted text preview: • The correlation between the conditions for NMDA receptor activation and the properties of LTP Possible Locus of Synaptic Plasticity • Number of Synapses • Strength of Synaptic Transmission at Individual Synapse • Efficacy of Charge Transfer from Synaptic Sites to Soma Background Reading: (Bear, 1996; Bi and Poo, 2001; Bliss and Collingridge, 1993; Liao et al., 1995; Malenka and Nicoll, 1999; Sanes and Lichtman, 1999; Zucker, 1999)...
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